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Biophotons, Microtubules & Brain
Light generated inside brain and the involvement of neuronal microtubules

Pablo Andueza Munduate

If the brain is related to mind is, from the point of view of the concept treated in this site, because the more complex and extensive multilayer electromagnetic fields working there, and if we test the possible role of biophotons we found that maybe they are very related because microtubules, more present in neurons that in other cells, are one of the very possible guiding mechanisms for those emissions. ...

Biophoton emission have been measured from numerous living systems including bacteria [1][2], cells [3], multicellular organisms [4], brain slices [5] etc.. and has been speculated about their possible role in information exchange and maybe consciousness generation.

It must be said first that biophoton emissions must have some energetic origin that can be modulated by organism or cell metabolism but this origin is not absolutely clear, or more exactly, various origins can be operating here. The classical theory proposes the action pathway related to oxygen-dependent mechanisms operated by oxidation-reduction enzymes of the respiratory chain, particularly cytochrome c oxidase (CcO).

But definitely is not the only source (even if possibly is a source), for example in [6] they found that:

" the initiation and/or maintenance of biophotonic activities can be significantly blocked by oxygen glucose deprivation together with the application of 2DG and cytochrome c oxidase inhibitor, but only partly by cytochrome c oxidase inhibitor, suggesting that the glutamate-induced biophotonic activities were dependent on energy metabolism and that alternative anaerobic metabolic pathways may be a compensatory method to meet energy requirements when the aerobic metabolic pathways are inhibited."

In a posterior experimental setup [31] there are used some known neurotransmitters like Acetylcholin, Dopamine or Norepinephrine to come to the conclusion that although glutamate-induced biophotonic activity and transmission in different neural circuits form the basic biophotonic information streams, the positive and negative regulation of glutamate action by other neurotransmitters may lead to altered states of consciousness.

It’s very interesting to see the other possible sources, one of them may be water [7][8], that has very interesting ordering capacities (see section [9]) and photon storage capacity [10].

DNA has also proposed as a possible source for biophotons (or Ultraweak Photon Emissions, UPE) [11], but if you are interested there is a section [12] in this web dedicated to more specifically discuss about possible physical origins of those electromagnetic emissions.

It is conceivable that evolution might have found a way to use these precious high-energy resources for information transfer, even if they are just the byproducts of metabolism (that for the editor of this site is not the winner idea), so it’s expected to find photon guiding or manipulating mechanisms in biological systems.

Newly discovered cell to cell membrane nanotubes are proposed as photonic waveguides for UPE [13] but there is more theoretical work developed with a similar proposition but related to axons of the cells/neurons [14], and in this case also more direct evidence is available [6]:

" we observed the glutamate-induced biophotonic activities in mouse sagittal brain slices and found that the extensive biophotonic activities were located at the area of the corpus callosum and the thalamus, and were significantly decreased by the application of PP2A inhibitor (OA), suggesting that the extensive biophotonic activities in these two areas may mainly originate from axons or axonal terminals in the corpus callosum and thalamus, respectively, which may be at least partly due to the active biophotonic transmission along the axons or axonal terminals of cortical projection neurons."

A posterior reanalysis of this hypothesis [32] confirmed that light conduction in a myelinated axon is feasible even in the presence of realistic imperfections in the neuron.

And more recently in a Nature publication [33] a model where are taken in consideration myalinated axons as waveguides and also the nodes of Ranvier that they will work like a nanoantenna array system able to radiate optical waves propagating through those myelinated axon is presented.

Sun et al. [15] discovered some year ago that stimulation with light at one end of the spinal sensory or motor nerve roots resulted in a significant increase in the biophotonic activity at the other end. They propose that light stimulation can generate biophotons that conduct along the neural fibers, probably as neural communication signals. In their paper they propose also that two different proteins may achieve biophotonic conduction if they form a biophotonic interaction couple and that this may be the mechanism of biophotonic conduction along neural fibers.

Rahnama et al. [16] propose that both the mitochondria and the microtubules could act as optical waveguides and taking in consideration that microtubules transmit electric signals between distant points within a neuron and the theoretical work that suggest that interaction of biophotons and microtubules causes transitions/fluctuations of microtubules between coherent and incoherent states, is also proposed also that biophotons can influence membrane electrical activity via microtubules.

Moreover, as axons are filled by microtubules, specially in neurons, is timely to note the interesting investigations that propose that biophotons are generated and conducted through microtubules by means of ordered water capacities as proposed in [8]:

" Micro-Tubules are considered as quantum cavities. Their role is to provide a single mode of biophoton field, in such a way that water molecules to be considered not as independent individuals, but rather as whole, in this manner water molecules are embedded in and interacting with a common radiation field.In the model proposed, collective behavior of water molecules is characterized by coherent water states analogous to Bloch states, whose main feature is to trap biophotons in a collective fashion."

Also is interesting to note that is known that the brain response can change dependent of an incident unique photon to the eye, so it is sensitive to the minimum quantum of energy, a unique photon![17] the brain is also sensitive to photons incident in other parts of the skull, that is, skull is permeable to photons and brain functioning is affected by the characteristics of photon sequences that pass through it [18][19]. There is a complete overview of the experimental investigation on the effect of low intensity light on living systems, including possible therapeutic application in this section [20].

There is a well developed hypothesis by Bokkon and others which proposes that biophotons may actually be the information from which dreams and visual images during the waking state are constructed. They have some experimental findings like spontaneous and visible light-induced photon emission from rat eyes, or that the photon-like component of discrete dark noise is not caused by a direct contribution of the thermal activation of rhodopsin, but rather by an indirect thermal induction of biophotonic activity, which then activates the retinal chromophore of rhodopsin. (See this section [21] to get more info about this theory).

Very curious and interesting may be the theory proposed by Grass [22]:

" The nervous system would have excellent conditions for a cell to cell communication by light. Neurons are large, metabolically very active (lightproducing) cells with wide arborisation, contain little pigment and are protected from ambient light by bone and connective tissue. Signal to noise ratio should be high for photon signals. It has been shown that light can be propagated along the axis tracts. Also the hollow microtubules (neurofibrillae) could act as light guiding structures. According to Jibu et al. their inner diameter of 15 nm is ideal for light guidance free of thermal noise and loss. Other findings that may be of importance in this context, are the strong flurescence properties of the major hallucinogens: LSD, bufetonine, dimethyl-tryptamine, psilocybine, psilocin, iboguanin, harmine, cannabidinol and mescaline. Furthermore it has been shown that hallucinogenic properties of these substances have a direct correlation to their fluorescence properties and their readyness to donate electrons. As hypothesis we propose that the fluorescence interacts physically with the proposed Biophoton mediated cell to cell communication thus producing hallucinations. This would be an easy and plausible explanation for the strong hallucinogenic properties of these fluorescent substances."

And, although away of the scope of this section, may be interesting to note that some investigations on nonlocality of mind take in consideration a possible important role of the biophoton emission characteristics [23] also, because biophoton emission and surrounding environmental geomagnetic intensity are inversely related [24] and manipulation of surrounding magnetic environment is related to these non-local phenomena (see section [25])

Biophotons generated by living systems can integrate in a more general framework of electromagnetic mind theory, as proposed in section [26], being a layer of this more general mind. How concrete is this layer or what are the specific qualia to what this layer is equal (or of what level of consciousness is representative) taking also in consideration the possibility that this electromagnetic layer is an upconversion of other coherent phenomena [27] is difficult to visualize at this moment. Anyway there are some concrete theories that relate biophotons with consciousness in some ways [28][29], in [30] is speculated that:

" the process of radiative relaxation of the electro-solitons allows for the transfer of energy via interactions with deoxyribonucleic acid (DNA) molecules to induce conformational changes in DNA molecules producing an ultra weak non-thermal spontaneous emission of coherent biophotons through a quantum effect. The instantiation of coherent biophotons confined in spaces of DNA molecules guides the biophoton field to be instantaneously conducted along the axonal and neuronal arbors and in-between neurons and throughout the cerebral cortex (cortico-thalamic system) and subcortical areas (e.g., midbrain and hindbrain). Thus providing an informational character of the electric coherence of the brain — referred to as quantum coherence. The biophoton field is realized as a conscious field upon the re-absorption of biophotons by exciplex states of DNA molecules."


1. Tilbury, R. N., and T. I. Quickenden. "Spectral and Time Dependence Studies of the Ultra-Weak Bioluminescence Emitted by the Bacterium Escherichia coli." Photochemistry and Photobiology 47.1 (1988): 145-150.

2. Trushin, Maxim V. "Light-mediated “conversation” among microorganisms." Microbiological research 159.1 (2004): 1-10.

3. Dotta, Blake T., et al. "Biophoton emissions from cell cultures: biochemical evidence for the plasma membrane as the primary source." General Physiology and Biophysics 30.3 (2011): 301.

4. Van Wijk, Eduard, Yu Yan, and Roeland Van Wijk. "Photon emission in multicellular organisms." Fields of the Cell (2015): 131–148.

5. Kobayashi, Masaki, et al. "In vivo imaging of spontaneous ultraweak photon emission from a rat’s brain correlated with cerebral energy metabolism and oxidative stress." Neuroscience research 34.2 (1999): 103-113.

6. Tang, Rendong, and Jiapei Dai. "Spatiotemporal imaging of glutamate-induced biophotonic activities and transmission in neural circuits." PloS one 9.1 (2014): e85643.

7. Karbowski, Lukasz M., and Michael A. Persinger. "Variable Viscosity of Water as the Controlling Factor in Energetic Quantities That Control Living Systems: Physicochemical and Astronomical Interactions." International Letters of Chemistry, Physics and Astronomy 4 (2015): 1.

8. Nistreanu, A. "Collective Behavior of Water Molecules in Microtubules." 3rd International Conference on Nanotechnologies and Biomedical Engineering. Springer Singapore, 2016.

9. EMMIND › Endogenous Fields & Mind › Water & Electromagnetic Fields › Electromagnetism & Water - Coherence Domains

10. Santana-Blank, Luis, et al. "“Quantum Leap” in Photobiomodulation Therapy Ushers in a New Generation of Light-Based Treatments for Cancer and Other Complex Diseases: Perspective and Mini-Review." Photomedicine and laser surgery 34.3 (2016): 93-101.

11. Rafii-Tabar, Hashem, and Neda Rafieiolhosseini. "Different Aspects of Ultra-weak Photon Emissions: A Review Article." Iranian Journal of Medical Physics 12.3 (2015): 137-144.

12. EMMIND › Endogenous Fields & Mind › Biophotons › Biophoton Sources

13. Scholkmann, Felix. "Long range physical cell-to-cell signalling via mitochondria inside membrane nanotubes: a hypothesis." Theoretical Biology and Medical Modelling 13.1 (2016): 1.

14. Kumar, Sourabh, et al. "Possible existence of optical communication channels in the brain." arXiv preprint arXiv:1607.02969 (2016).

15. Sun, Yan, Chao Wang, and Jiapei Dai. "Biophotons as neural communication signals demonstrated by in situ biophoton autography." Photochemical & Photobiological Sciences 9.3 (2010): 315-322.

16. Rahnama, Majid, et al. "Emission of mitochondrial biophotons and their effect on electrical activity of membrane via microtubules." Journal of integrative neuroscience 10.01 (2011): 65-88.

17. Tinsley, Jonathan N., et al. "Direct detection of a single photon by humans." Nature Communications 7 (2016).

18. Sun, Lihua, et al. "Human Brain Reacts to Transcranial Extraocular Light." PloS one 11.2 (2016): e0149525.

19. Karbowski, Lukasz M., et al. "LORETA indicates frequency-specific suppressions of current sources within the cerebrums of blindfolded subjects from patterns of blue light flashes applied over the skull." Epilepsy & Behavior 51 (2015): 127-132.

20. EMMIND › Applied Fields - Experimental › Light & Near-Light Effects

21. EMMIND › Endogenous Fields & Mind › Biophotons › Biophotons Bókkon's Theory of Vision

22. Grass, F. "P03-33-Biophotons, hallucinogens, and fluorescence." European Psychiatry 26 (2011): 1202.

23. Tressoldi, Patrizio E., et al. "Mental Interaction at Distance on a Photomultiplier: A Pilot Study." Available at SSRN 2506135 (2014).

24. Persinger, Michael A., et al. "Inverse relationship between photon flux densities and nanotesla magnetic fields over cell aggregates: Quantitative evidence for energetic conservation." FEBS open bio 5 (2015): 413-418.

25. EMMIND › Nonlocality & Fields › Nonlocal Distant Mind Influence › The Electromagnetism Active Role

26. EMMIND › Endogenous Fields & Mind › Endogenous Electromagnetic Fields › Electromagnetic Mind - Principal

27. Swain, John. "On the possibility of large upconversions and mode coupling between frohlich states and visible photons in biological systems." arXiv preprint physics/0603137 (2006).

28. Grass, F., Herbert Klima, and S. Kasper. "Biophotons, microtubules and CNS, is our brain a “Holographic computer”?." Medical hypotheses 62.2 (2004): 169-172.

29. Simanonok, Karl. "Endogenous Light Nexus Theory of Consciousness." (2008).

30. Cacha, Lleuvelyn A., and Roman R. Poznanski. "Genomic instantiation of consciousness in neurons through a biophoton field theory." Journal of integrative neuroscience 13.02 (2014): 253-292.

31. Chai, Weitai, et al. "Biophotonic Activity and Transmission Mediated by Mutual Actions of Neurotransmitters are Involved in the Origin and Altered States of Consciousness." Neuroscience bulletin 34.3 (2018): 534-538.

32. Zarkeshian, Parisa, et al. "Are there optical communication channels in the brain?." arXiv preprint arXiv:1708.08887 (2017).

33. Zangari, Andrea, et al. "Node of Ranvier as an array of bio-nanoantennas for infrared communication in nerve tissue." Scientific reports 8.1 (2018): 539.

34. Shi, Lingyan, Enrique J. Galvez, and Robert R. Alfano. "Photon entanglement through brain tissue." Scientific reports 6 (2016): 37714.

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text updated: 18/09/2018
tables updated: 12/03/2020

Endogenous Fields & Mind
Biophotons, Microtubules & Brain

Biophotons, Microtubules & Brain

(F) Full or (A) Abstract

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Publication Year (and Number of Pages)

Favailable in PDF and HTMLThe Mystery of Chemotherapy Brain: Kynurenines, Tubulin and Biophoton ReleaseCommentary icon2020-(12)Peter P. Sordillo, Laura A. Sordillo
Aavailable in HTMLGlutamate-Induced Biophotonic Activities Show Spectral Blueshift in Aging MiceCommentary icon2019-(1)Lin-hua Chen, Zhuo Wang, Cheng-ming Xia, Fang-yan Xiao, Jia-pei Dai
Favailable in PDF and HTMLThe Characteristics of Biophotonic Activity Induced by Aspartate May Be Related to the Evolution of SpeciesCommentary icon2019-(7)Shuangqiong Tan, Chi Xu, Jia-pei Dai
Favailable in PDF, HTML and EpubOn the existence of superradiant excitonic states in microtubules (microtubules)Commentary icon2019-(30)G. L. Celardo, M. Angeli, P. Kurian, T. J. A. Craddock
Aavailable in HTMLA new theory based on possible existence of timing control by intracellular photons in tonically active neuronsCommentary icon2019-(1)Hossein Mofidi, Yashar Sarbaz, Saeed Golmohammadi
Favailable in PDFQuantum energy levels of glutamate modulate neural biophotonic signalsNo comments yet icon2018-(32)Zhengrong Han, Weitai Chai, Zhuo Wang, Fangyan Xiao, Jiapei Dai
Favailable in PDF and HTMLThe gastrointestinal-brain axis in humans as an evolutionary advance of the root-leaf axis in plants: A hypothesis linking quantum effects of light on serotonin and auxinCommentary icon2018-(7)Lucio Tonello, Bekim Gashi, Alessandro Scuotto, Glenda Cappello, Massimo Cocchi, Fabio Gabrielli, Jack A. Tuszynski
Favailable in PDFBiophotonic Activity and Transmission Mediated by Mutual Actions of Neurotransmitters are Involved in the Origin and Altered States of ConsciousnessNo comments yet icon2018-(5)Weitai Chai, Zhengrong Han, Zhuo Wang, Zehua Li, Fangyan Xiao, Yan Sun, Yanfeng Dai, Rendong Tang, Jia-pei Dai
Aavailable in HTMLBiophotonic Transmission in Relation to Intelligence and ConsciousnessNo comments yet icon2018-(1)Jia-pei Dai
Favailable in HTMLAre there optical communication channels in the brain? (myelinated axons)No comments yet icon2017-(?)Parisa Zarkeshian, Sourabh Kumar, Jack Tuszýnski, Paul Barclay, Christoph Simon
Favailable in PDF and HTMLPhoton Entanglement Through Brain Tissue (applied light)Commentary icon2016-(6)Lingyan Shi, Enrique J. Galvez, Robert R. Alfano
Favailable in PDF and HTMLWhen Is the Brain Dead? Living-Like Electrophysiological Responses and Photon Emissions from Applications of Neurotransmitters in Fixed Post-Mortem Human BrainsNo comments yet icon2016-(26)Nicolas Rouleau, Nirosha J. Murugan, Lucas W. E. Tessaro, Justin N. Costa, Michael A. Persinger
Favailable in PDF and HTMLHuman high intelligence is involved in spectral redshift of biophotonic activities in the brainCommentary icon2016-(6)Zhuo Wang, Niting Wang, Zehua Li, Fangyan Xiao, Jiapei Dai
Favailable in PDF and HTMLDifferential Spontaneous Photon Emissions from Cerebral Hemispheres of Fixed Human Brains: Asymmetric Coupling to Geomagnetic Activity and Potentials for Examining Post-Mortem Intrinsic Photon InformationNo comments yet icon2016-(11)Nicolas Rouleau, Lucas W. E. Tessaro, Kevin S. Saroka, Mandy A. Scott, Brendan S. Lehman, Lyndon M. Juden-Kelly, Michael A. Persinger
Favailable in PDF and HTMLLagged Coherence of Photon Emissions and Spectral Power Densities between the Cerebral Hemispheres of Human Subjects during Rest Conditions: Phase Shift and Quantum PossibilitiesCommentary icon2016-(7)J. N. Costa, B. T. Dotta, M. A. Persinger
Favailable in PDFHolographic Memory: Magnetite Nano-Devices for Bio-Photonic Representations in the Human Brain NeocortexNo comments yet icon2015-(63)Marcos Martinez Banaclocha
Favailable in PDFAnthropologic analysis of human body emissions using new photographic technologiesNo comments yet icon2015-(7)Paolo Debertolis, Daniele Gullà
Aavailable in HTMLCollective Behavior of Water Molecules in Microtubules (microtubules)No comments yet icon2015-(5)A. Nistreanu
Favailable in PDFUltraweak photon emission in the brainNo comments yet icon2015-(11)V. Salari, H. Valian, H. Bassereh, I. Bókkon, A. Barkhordari
Favailable in PDFSuperradiant coherent photons and hypercomputation in brain microtubules considered as metamaterialsNo comments yet icon2015-(13)Luigi Maxmilian Caligiuri, Takaaki Musha
Favailable in PDFEntanglement Between Bio-Photons and Tubulins in Brain: Implications for Memory Storage and Information ProcessingNo comments yet icon2014-(6)Mohsen Ostovari, Abolfazl Alipour, Alireza Mehdizadeh
Favailable in PDFGenomic instantiation of consciousness in neurons through a biophoton field theoryNo comments yet icon2014-(40)Lleuvelyn A. Cacha, Roman R. Poznanski
Aavailable in HTMLBiophoton signal transmission and processing in the brainNo comments yet icon2014-(1)Rendong Tang, Jiapei Dai
Favailable in PDF, HTML and EpubSpatiotemporal Imaging of Glutamate-Induced Biophotonic Activities and Transmission in Neural CircuitsNo comments yet icon2014-(8)Rendong Tang, Jiapei Dai
Favailable in PDF and HTMLMagnetic Field Configurations Corresponding to Electric Field Patterns That Evoke Long-Term Potentiation Shift Power Spectra of Light Emissions from Microtubules from Non-Neural CellsNo comments yet icon2014-(8)Michael A. Persinger, Blake T. Dotta, David A.E. Vares, Carly A. Buckner, Robert M. Lafrenie
Favailable in PDFConvergence of Numbers of Synapses and Quantum Foci Within Human Brain Space: Quantitative Implications of the Photon as the Source of CognitionNo comments yet icon2014-(8)Michael A. Persinger
Favailable in PDFCongruence of Energies for Cerebral Photon Emissions, Quantitative EEG Activities and ~5 nT Changes in the Proximal Geomagnetic Field Support Spin-based Hypothesis of ConsciousnessNo comments yet icon2013-(24)Michael A. Persinger , Blake T. Dotta, Kevin S. Saroka, Mandy A. Scott
Favailable in PDFConcurrent Photon Emission, Changes in Quantitative Brain Activity over the Right Hemisphere, and Alterations in the Proximal Geomagnetic Field While Imagining White LightNo comments yet icon2013-(5)Kevin S. Saroka, Blake T. Dotta, Michael A. Persinger
Aavailable in HTMLBiophotons, hallucinogens, and fluorescenceNo comments yet icon2011-(1)F. Grass
Favailable in PDFOn the Photonic Cellular Interaction and the Electric Activity of Neurons in the Human BrainNo comments yet icon2011-(9)Vahid Salari, Jack A. Tuszynski, István Bókkon, Majid Rahnama, Michal Cifra
Favailable in PDFEmission of mitochondrial biophotons and their effect on electrical activity of membrane via microtubulesNo comments yet icon2010-(22)Majid Rahnama, Jack A. Tuszynski, István Bókkon, Michal Cifra, Peyman Sardar, Vahid Salari
Favailable in PDFBiophotons as neural communication signals demonstrated by in situ biophoton autographyCommentary icon2010-(8)Yan Sun, Chao Wang, Jiapei Dai
Favailable in HTMLEndogenous Light Nexus Theory of ConsciousnessCommentary icon2008-(23)Karl Simanonok
Aavailable in HTMLBiophotons, microtubules and CNS, is our brain a “Holographic computer”?Commentary icon2003-(1)F. Grass, H. Klima
 Not biophotons but brothers :)
Favailable in PDFElectromagnetic Propagation Models in Nerve Fibers (myelinated axons)Commentary icon2019-(4)Qingwei Zhai, Kelvin J. A. Ooi, C. K. Ong, Shengyong Xu
Favailable in PDF and HTMLOn the delay in propagation of action potentials (myelinated and unmelyneated axons)Commentary icon2019-(18)J. Xu, S. Xu, F. Wang, S. Xu
Favailable in PDFCell vibron polariton in the myelin sheath of nerve (myelinated axons)No comments yet icon2019-(16)Bo Song, Yousheng Shu
Aavailable in HTMLMyelin Sheath as a Dielectric Waveguide for Signal Propagation in the Mid‐Infrared to Terahertz Spectral Range (myelinated axons)No comments yet icon2018-(1)Guozhi Liu, Chao Chang, Zhi Qiao, Kaijie Wu, Zhi Zhu, Gangqiang Cui, Wenyu Peng, Yuzhao Tang, Jiang Li, Chunhai Fan
Favailable in PDF and HTMLNode of Ranvier as an Array of Bio-Nanoantennas for Infrared Communication in Nerve Tissue (between Ranvier nodes)Commentary icon2018-(19)Andrea Zangari, Davide Micheli, Roberta Galeazzi, Antonio Tozzi
Favailable in PDF and HTMLPossible existence of optical communication channels in the brain (myelinated axons)No comments yet icon2016-(24)Sourabh Kumar, Kristine Boone, Jack Tuszýnski, Paul Barclay, Christoph Simon
Aavailable in HTMLSpatiotemporal Imaging of Water in Operating Voltage-Gated Ion Channels Reveals the Slow Motion of Interfacial IonsCommentary icon2019-(1)Orly B. Tarun, Maksim Yu. Eremchev, Aleksandra Radenovic, Sylvie Roke



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