Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy

" As opposed to the uniform static magnetic field that is being measured by magnetoencephalography (MEG), here we model and precisely describe how temporal and spatial propagation of an action potential, and subsequent intracellular and extracellular current flow, generates an inhomogeneous time-varying electromagnetic field which serves as a source of the field recorded by MEG. Due to the insulating nature of the myelin sheath, this field presents itself as a magnetic field at myelinated regions of the axon and an electromagnetic field at the nodes of Ranvier.

By using advanced mathematic modeling, supported by experimental proof of concept, we demonstrate that the electromagnetic fields generated around the neurons significantly, in extent much higher than thought before, influence the migration, adhesion and activity of negatively charged cells." {Credits 1}

" Interestingly, the fields that are described in this paper are, actually, the same fields detected by MEG. The reason why MEG detects fields of 10−15 T is not only the distance from the source but also their inhomogeneity, which our model precisely describes. Thus, our model, in much more detail, quantifies the electromagnetic fields in the nervous system and explains the nature of the signal detected by MEG. With this, both the electromagnetic fields described by our model and the magnetic field detected by MEG, are valid and interconnected. One is observing the micro values of the electromagnetic field strength at levels of cells and single axons, such as described by our model, and the other detects the macro-values of the magnetic field strength, such as seen on MEG." {Credits 1}

" If the concept of “electromagnetic receptors” that we present in this paper is to be proven, it would suggest that the reason the cells initiate the immune response for the destruction of the myelin sheath is because they recognize the existence of a non-uniform magnetic field around the myelinated segments and, in accordance with laws of physics, no changing magnetic field created in our body can be isolated from an electric field. Since every non-uniform time-varying magnetic field in nature generates an induced electric field, the “electromagnetic receptors” could recognize the non-existence of a detectable electric field, which is shielded by the myelin sheath, as a sign of an external pathogen that is harmful to the normal workings of our body and is impacting the functionality of the CNS." {Credits 1}

" If a neuron is to be degenerated to such an extent that it can no longer conduct impulses, no electromagnetic field will be detected around that region and, with that, the region will be seen, again, as an external pathogen and the cells will initiate a response to aid its regeneration or cause further damage." {Credits 1}

{Credits 1} 🎪 Isakovic, J., Dobbs-Dixon, I., Chaudhury, D. et al. Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy. Sci Rep 8, 12909 (2018) doi:10.1038/s41598-018-31054-9. © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License.

Last modified on 10-Sep-18

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