" ... Non-static organism-scale electric fields also, however, appear to play a role in developmental regulation and tumor suppression (139, 140). Chernet, Fields and Levin (141) showed that in Xenopus embryos, enhancing or facilitating gap-junction communication between cells on one side of the embryo resulted in differential response to KRAS-mediated tumor induction on the opposite side. As shown in Fig. 7, a model that assumes that cells on the left and right sides exchange a “handshaking” signal via an oscillatory electric field quantitatively reproduces the tumor-response observations across a broad range of treatment conditions. ..."
Last modified on 19-Aug-18