GlymphoVasomotor Field (GVF) theory: a non-neuronal scaffolding for brain rhythms and consciousness

" GVF suggests that rhythmic release of norepinephrine (NE) by the locus coeruleus during sleep initiates oscillatory vasomotion of cerebral vessels, driving cerebrospinal fluid (CSF) flow within electrically conductive perivascular spaces. This ionic CSF movement generates structured, oscillating electromagnetic fields capable of modulating cortical neuronal activity and coherence. GVF theory thus posits EEG rhythms as possible reflections of vascular-CSF field dynamics rather than pure neuronal activity. This framework helps resolve discrepancies between IIT and GNWT, particularly in explaining posterior–frontal co-activation, temporal continuity of conscious content, and functional connectivity without direct synaptic coupling." {Credits 1}

{Credits 1} 🎪 Bhatt, S. S., Sbaih, O., Habermann, S., Shahrour, N., Weatherdon, E., & Tornatore, C. (2025). GlymphoVasomotor Field (GVF) theory: a non-neuronal scaffolding for brain rhythms and consciousness. Medical Hypotheses, 111763. © 2025 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License.