Inventing atomic resolution scanning dielectric microscopy to see a single protein complex operation live at resonance in a neuron without touching or adulterating the cell


" We electromagnetically triggered electrical, mechanical, thermal and ionic resonant vibrations in a protein … We image live that a protein molecule adopts a unique configuration for each resonance frequency, thus far unknown to biology. "Membrane alone fires" is found to be wrong after a century, micro-neuro-filaments communicate prior to firing to decide its necessity and then regulate it suitably. We introduce a series of technologies e.g., fractal grid, point contact, micro THz antenna, to discover that from atomic structure to a living cell, the biomaterials vibrate collectively."

As is specified in the paper the components of a living cell are interconnected over the entire electromagnetic frequency range.

They use their new developed technologies to do simultaneous imaging of ionic, electric and electromagnetic transmissions.

" We found the resonance frequencies of a particular spatial location on the neuron, at which frequency the maximum resistance change takes place. Then we have plotted the frequencies [Fig. 6(a)]. The plot shows that a neural network is in reality a network of electromagnetic coupling."

Experimental data shows that there is a collective dielectric coupling between the axon core, microtubules/actins and the proteins residing inside the neuron. And they found evidence that an alternate form of communication (electromagnetic) in the neuron precedes the ionic firing.

" We have studied the mechanical, ionic, electrical and electromagnetic resonance in neural firing and it is found that they all are connected together, neural firing's 100-year old myth that ionic conduction does everything is shattered with a series of experiments. Two observations, first, dielectric coupling from the cavities of a monomer of a protein to the neural network [see Fig. 6(a)], second, direct evidence of effective, logical signal transmission in the MHz frequency range at least 20–30 μs earlier than the emergence of a nerve impulse."

It can be addressed here that an information processing inside neurons before spiking activity is sustained by other investigations, as is expressed in a review by D. Aur et al. [1]:

" Recent physiological investigations within in vivo experimental data and changes in spike directivity reveal that computations are built at different scales inside the neuron shaped by molecular interactions, regulating genes, and protein expression. All these phenomena remodel how electric interactions are performed and implicitly how information is processed and stored inside the neuron. "

[1] Aur, D., Jog, M., & Poznanski, R. R. (2011). Computing by physical interaction in neurons. Journal of integrative Neuroscience, 10(04), 413-422.


Last modified on 11-Feb-18

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