5G Radiofrequency Exposure Reduces PRDM16 and C/EBP β mRNA Expression, Two Key Biomarkers for Brown Adipogenesis

" Our research showed a fold change decrease of 49% for PRDM16 and 32% for C/EBP β in terms of their mRNA levels after exposure to 5G. As mentioned previously, these adipogenic markers are important in the differentiation and maturation of brown adipocytes from BAT precursors, as well as the maintenance of their thermogenic capacity. In contrast, UCP1-dependent thermogenesis was not impacted by RF exposure at the transcriptional level. Most of the studied thermogenic markers showed no age-related or exposure duration-related effects associated with RF exposure, except for PPAR α and ADRβ3. This study provides new insights into the potential impact of 5G exposure on brown adipogenesis. The disrupted differentiation and thermogenic capacity of brown adipocytes through PRDM16 and C/EBP β downregulation may affect the development and characteristics of BAT, potentially leading to increased cold sensitivity after RF exposure. These findings could partially explain the physiological events related to cold stress seen after RF exposures."

{Credits 1} 🎪 Seewooruttun, C.; Bouguila, B.; Corona, A.; Delanaud, S.; Bodin, R.; Bach, V.; Desailloud, R.; Pelletier, A. 5G Radiofrequency Exposure Reduces PRDM16 and C/EBP β mRNA Expression, Two Key Biomarkers for Brown Adipogenesis. Int. J. Mol. Sci. 2025, 26, 2792. https://doi.org/10.3390/ijms26062792. © 2025 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License.