" animal weight was lower at first, second and fourth month. the mean testis weight was significantly reduced in all months except fourth month and the mean testis volume was significantly reduced in the first three months.the mean seminiferous tubule density per unit area was significantly lower value. the mean seminiferous tubule diameter was significantly reduced except the second month. the mean number of Sertoli cells and Leydig cells were significantly reduced. mean serum testosterone level were significantly lower. microscopic changes: 1. the interstitium appeared wide 2. Sertoli cells and spermatogonia were detached from the basal lamina. 3. vacuolar degeneration and desquamation of seminiferous epithelium. most of the peripheral tubules showed maturation arrest in the spermatogenesis. seminiferous tubules scored between 8 and 9 using Johnson testicular biopsy score count."
Last modified on 10-Apr-16