Cancer induction molecular pathways and HF-EMF irradiation

Numerous data and experimental results are shown in this review.

" There are many examples of biological effects involving the epigenome. EMFs could trigger protein activation mediated by ligands, such as Ca 2+ , that alter the conformation of binding proteins, especially the NADPH plasmic membrane oxidase, so inducing increased formation of reactive oxygen species (ROS) that may alter proteomic functions. Classical anti-apoptotic and procarcinogenic signaling pathways that are commonly found activated in human malignancies and in inflammation mainly involve the transcription factor NF- κ B. The microenvironment that exists during chronic infla mmation can contribute to cancer progression. The data support the proposition that long term HF-EMF exposure associated with improper use of cell phones can potentially cause cancer." {Credits 1}

They are revised various posibles targets of radiation including water:

" Microwave (MW) exposure at the water resonance frequency, i.e . exposure to radiofrequencies between about 1 GHz and 300 GHz, was able to induce alteration of the mitotic apparatus and apoptosis as a function of the applied power densities (5 and 10 mW/cm 2 ), together with a moderate reduction in the rate of cell division." {Credits 1}


" Microtubule fibers represent extremely dynamic structure which functioning depends on dynamical instability that is continuously binding and releasing of free tubule proteins. One can reasonably assume that the external EM radiation might interact with polar cytoskeletal structure." {Credits 1}

..And membrane:

" He concluded that conformational changes arising from alterations in charge distribution play a key role in membrane transport proteins, including ion channels. Thus, weak EMFs can control and amplify biological processes through their effects on charge distribution." {Credits 1}

" Panagopoulos et al . [39] have suggested that oscillating ions during forced vibration will also exert mechanical force-pressure on the plasma membrane able to upset the membrane electrochemical balance, under certain conditions, by opening or closing mechanically gated channel proteins, like some Ca influx channels." {Credits 1}

Also they point out how the oxidative stress that the radiation provoques can be associated with increases tumor risk.

{Credits 1} 🎪 Ledoigt, G. and Belpomme, D. (2013) Cancer induction pathways and HF-EMF irradiation. Advances in Biological Chemistry, 3, 177-186. doi: 10.4236/abc.2013.32023. © 2013 Gérard Ledoigt, Dominique Belpomme et al. This is an open access article distributed under the Creative Commons Attribution License.

Last modified on 15-Mar-16

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