HEK293 cell response to static magnetic fields via the radical pair mechanism may explain therapeutic effects of pulsed electromagnetic fields


It is very interesting that the lowest static magnetic field intensity used is that which causes changes in gene expression:

" These results can be summarized as follows: when cells were exposed to the LLF condition, they were effectively deprived of the Earth’s magnetic field. This led to a marked increase in expression of ROS-related genes (Fig 1), indicating that physiological ROS synthesis is much lower in the presence of the local (Earth’s) geomagnetic field. Higher magnetic field strengths showed no measurable further effect on ROS-related gene expression. This indicates that regulation of cellular ROS is optimal in the presence of the geomagnetic field." {Credits 1}

(LLF is the 0.0002 mT magnetic field exposure, Earth's geomagnetic field in the location was 0.04 mT)

" Even a 10 min exposure to LLF was effective in stimulating increased expression in our selected genes. The level of induction was comparable to that obtained from these cultured cells subsequent to exposure to the 10 Hz PEMF signal [23]. Intriguingly, two of the three genes responded similarly after a 3-hour exposure period (RPS16P5, TAS2R19). However, one of the genes (KIAA1211) proved insensitive to 3 hours of continuous exposure to LLF. This suggests some degree of adaptation over the longer term, a common feature of cellular response to altered concentration of ROS [33]." {Credits 1}

{Credits 1} 🎪 Pooam M, Jourdan N, El Esawi M, Sherrard RM, Ahmad M (2020) HEK293 cell response to static magnetic fields via the radical pair mechanism may explain therapeutic effects of pulsed electromagnetic fields. PLoS ONE 15(12): e0243038. © 2020 Pooam et al. This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.


Last modified on 04-Dec-20

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