Effects of the signal modulation on the response of human fibroblasts to in vitro stimulation with subthermal RF currents

The authors apply minute electric fields to human fibroblast but not constantly but at two radifrecuency signals: a 448-kHz, non-modulated sinusoidal wave and a 448-kHz carrier signal amplitude modulated to a 20-kHz frequency.

The modulated signal is found to cause more pronounced effects (Hsp27 and decorin overexpression and promotion of cell proliferation).