Photobiomodulation invigorating collagen deposition, proliferating cell nuclear antigen and Ki67 expression during dermal wound repair in mice

The lesser fluence (2 J/cm2), because of the lowest exposure time, reached major effects than the longer fluence/exposure time:

" The positive influence of red light on collagen synthesis was found to be statistically significant on day 10 (P < 0.01) and day 15 (P < 0.05) post-wounding when compared to sham irradiation, as evident from the image analysis of collagen birefringence. Furthermore, a significant rise in PCNA (P < 0.01) and Ki67 (P < 0.05) expression was also recorded in animals exposed to 2 J/cm2 when compared to sham irradiation and (P < 0.01) compared to the 10 J/cm2 treated group as evidenced by the microscopy study. The findings of the current investigation have distinctly exhibited the assenting influence of red laser light on excisional wound healing in Swiss albino mice by augmenting cell proliferation and collagen deposition." {Credits 1}

{Credits 1} 🎪 Prabhu, V., Rao, B.S.S., Rao, A.C.K. et al. Photobiomodulation invigorating collagen deposition, proliferating cell nuclear antigen and Ki67 expression during dermal wound repair in mice. Lasers Med Sci (2020). https://doi.org/10.1007/s10103-020-03202-z. © 2020 The authors. This is an open access article distributed under the terms of the Creative Commons Attribution license.