The Dynamic(s) of Adipose Stem Cell System, Their Survival, and Cessation under the Influence of Electromagnetic Fields

" In this study, EMF parameters were calculated to influence Ca 2+ and Mg 2+ ions which are essential in signal transduction pathways (such as cell division and growth), cell metabolism, and cell death [11-13]. Ca 2+ ions act as a mediator changing for example the transmembrane potential and may act as a mediator in the interaction with the EMF. The parameters based on ICR can tune the frequency to that characteristic for individual ions, thereby selectively changing ion concentration in the cell [4,14]. These changes may lead to pathophysiological cell responses, such as increased cell death, reported in this study [Figure 2a]." {Credits 1}

" In this study, a statistically significant increase of proliferation after 24 h of continuous exposure to EMF was observed. A decrease in proliferation after 12 h might be due to a superoxide anion formation induced by disturbing Ca 2+ influx through EMF stimulation, whereby a proliferation increase after 24 h manifests when cells achieve a redox balance [Figure 2a] [16-18]. Increased proliferation may also be due to higher concentrations of pro-proliferative FGF-2 protein, secreted by ASCs. Previous study has already demonstrated that after 24 h of EMF (50 Hz) exposure, ASCs secrete an increased amount of FGF-2 [7]." {Credits 1}

{Credits 1} 🎪 Trzyna A, Bądziul DB, Jakubczyk P, Bocak DS, Cholewa M, Banaś-Ząbczyk A. The dynamic(s) of adipose stem cell system, their survival, and cessation under the influence of electromagnetic fields. J Med Phys 2021;46:148-53. © 2021 Journal of Medical Physics. This article is licensed under the Creative Commons s Attribution‑NonCommercial‑ShareAlike 4.0 License.