Extremely Low-Frequency Electromagnetic Fields Affect Myogenic Processes in C2C12 Myoblasts Role of Gap-Junction-Mediated Intercellular Communication

" The ELF-EMFs did not affect C2C12 myoblast viability or proliferation rate. Conversely, at ELF-EMF intensity in the mT range, the myogenic process was accelerated, through increased expression of MyoD, myogenin, and connexin 43. The increase in gap-junction function suggests promoting cell fusion and myotube differentiation." {Credits 1}

Paper shows some increases of differentiation of C2C12 myoblasts into myotubes

" MyoD and myogenin expression levels showed some increases for the C2C12 myoblasts exposed to ELF-EMF treatments, with respect to the corresponding control cells (Figure 3). For the ELF-EMF treatment with 0.1 mT, this increase was evident only for myogenin expression after 72 hours of exposure. The exposure to 0.5 mT intensity triggered an increase of MyoD expression at 48 hours and of myogenin expression at 24 and 48 hours. Differently, 1.0 mT induced increased MyoD expression at 24 hours and increased myogenin expression at 72 hours of exposure." {Credits 1}

{Credits 1} 🎪 Morabito, C., Steimberg, N., Rovetta, F., Boniotti, J., Guarnieri, S., Mazzoleni, G., & Mariggiò, M. A. (2017). Extremely low-frequency electromagnetic fields affect myogenic processes in C2C12 myoblasts: Role of Gap-junction-mediated intercellular communication. BioMed research international, 2017. Copyright © 2017 Caterina Morabito et al. This is an open access article distributed under the Creative Commons Attribution License.

Last modified on 22-Sep-18

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