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Electromagnetism & Morphogenetics
Fields guiding the positioning of organelles in cells, cells in organs, and organs in bodies

Pablo Andueza Munduate

Is being discovered that electromagnetic (EM) fields has a lot of to do with the creation and maintenance of the form in biological systems, in all scales, from cellular to bodies, guiding morphogenetic processes. As electromagnetic mind theory must include facts like cellular mind [1] it is proposed that a kind of basic EM mind is always included, because of those morphogenetic fields. ...

In this sense they are specially valued the works of Pietak [2,3] although they are no experimantally proven, where the three dimensional architectures of developing plant flower buds show striking parallels with resonance patterns formed by electromagnetic energy.

But is not the principal line of investigation on the morphogenetic - EM fields relation, they are more experimentally proved issues like electric currents that guide the migration of cells; for example Cao et al. [4] reported electric field dependent migration of neuroblasts, and as reviewed by Levin et al. [5] specific voltage range is necessary for demarcation of eye fields in the frog embryo and artificially setting other somatic cells to the eye-specific voltage range resulted in formation of eyes in aberrant locations, including tissues that are not in the normal anterior ectoderm lineage: eyes could be formed in the gut, on the tail, or in the lateral plate mesoderm. Or as also Levin et al. [6] mentioned:

" The genome is tightly linked to bioelectric signaling, via ion channel proteins that shape the gradients, downstream genes whose transcription is regulated by voltage, and transduction machinery that converts changes in bioelectric state to second-messenger cascades. However, the data clearly indicate that bioelectric signaling is an autonomous layer of control not reducible to a biochemical or genetic account of cell state."

Or as also he wrote in [7]:

" Early frog embryos exhibit a characteristic hyperpolarization of cells lining the neural tube; disruption of this spatial gradient of the transmembrane potential (Vmem) diminishes or eliminates the expression of early brain markers, and causes anatomical mispatterning of the brain, including absent or malformed regions. This effect is mediated by voltage-gated calcium signaling and gap-junctional communication."

Wells [8] focused on plasma membrane patterns that generate endogenous electric fields that provide three-dimensional coordinate systems for embryo development. In a review by Funk [9] he distinguishes two type of issues: membrane potential of low magnitude and related electric fields (bioelectricity), and cell migration under the guiding cue of electric fields (EF). He described for example how in osteoblasts, the directional information of EF is captured by charged transporters on the cell membrane and transferred into signaling mechanisms that modulate the cytoskeleton and motor proteins resulting in a persistent directional migration along an EF guiding cue.

Michael Levin (as it can be seen one of the scientific more prolific in this research topic) and Maria Lobikin realised a review [10] where is well described the issues related to endogenous bioelectric currents, just as they wrote in the abstract:

" Complex pattern formation requires mechanisms to coordinate individual cell behavior towards the anatomical needs of the host organism. Alongside the well-studied biochemical and genetic signals functions an important and powerful system of bioelectrical communication. All cells, not just excitable nerve and muscle, utilize ion channels and pumps to drive standing gradients of ion content and transmembrane resting potential. In this chapter, we discuss the data that show that these bioelectrical properties are key determinants of cell migration, differentiation, and proliferation. We also highlight the evidence for spatio-temporal gradients of transmembrane voltage potential as an instructive cue that encodes positional information and organ identity, and thus regulates the creation and maintenance of large-scale shape. In a variety of model systems, it is now clear that bioelectric prepatterns function during embryonic development, organ regeneration, and cancer suppression."

It must be say, that the relationship of those facts with the electromagnetic mind (and live) theory resides in that the form is what the things do to be and function as they do and that if this is dependent at least of the electric field (one of the component of the electromagnetic fields) we can have a some kind of hint in this direction, electromagnetism having two component they can each of they represent some kind of basic life or mind process complementary between them (it is very philosophical issue but it can be related also to the works of Pietak [2,3] when each of this two components are interchangeable but always representing opposite position/function like the seeds on one side and external walls on the other):

" ..Similar to the abutilon ovary and squash male flower bud, cells in the female squash ovary in regions that correlate to highest electric field strength have changed into placental tissue cells, while the six places of high magnetic field strength are also the six places where ova form in the squash ovary (Figure 5).."

" Overall, the structural evidence and physical uniqueness of EM mode patterns indicates developing plant organs can support EM resonances, whereby the electric and magnetic field components guide symmetry-breaking and therefore resemble the first pattern to emerge in primordia. Rich in positional information, the EM resonant mode represents a possible physical manifestation of the morphogenetic field."

The question of what can be the source of those endogenous EM are treated in other sections, for example Fröhlich propose and theorize a EM production in a range from 1011 to 1112 Hz (the same frequency range as proposed in the above mentioned Pietak papers) and this have a specific section on this site [11], water and its interactions in coherent domains [12] or microtubule vibrations [13] can be also a source, and of course it must be taken into account that we are all living under a giant EM resonator that is our planet ionosphere.

References:

1. Jon Lieff → Cellular Intelligence

2. Pietak, Alexis Mari. "Electromagnetic resonance and morphogenesis." Fields of the Cell (2015): 303–320. ISBN: 978-81-308-0544-3.

3. Pietak, Alexis Mari. "Structural evidence for electromagnetic resonance in plant morphogenesis." Biosystems 109.3 (2012): 367-380.

4. Cao, Lin, et al. "Endogenous electric currents might guide rostral migration of neuroblasts." EMBO reports 14.2 (2013): 184-190.

5. Tseng, AiSun, and Michael Levin. "Cracking the bioelectric code: probing endogenous ionic controls of pattern formation." Communicative & integrative biology 6.1 (2013): 13192-200.

6. Levin, Michael. "Endogenous bioelectrical networks store non‐genetic patterning information during development and regeneration." The Journal of physiology 592.11 (2014): 2295-2305.

7. Pai, Vaibhav P., et al. "Endogenous gradients of resting potential instructively pattern embryonic neural tissue via notch signaling and regulation of proliferation." The Journal of Neuroscience 35.10 (2015): 4366-4385.

8. Wells, Jonathan. "Membrane patterns carry ontogenetic information that is specified independently of DNA." BIO-complexity 2014 (2014).

9. Funk, Richard HW. "Endogenous electric fields as guiding cue for cell migration." Frontiers in physiology 6 (2015): 143.

10. Lobikin, Maria, and Michael Levin. "Endogenous bioelectric cues as morphogenetic signals in vivo." Fields of the Cell (2015): p. 283–302. ISBN: 978-81-308-0544-3.

11. EMMIND › Endogenous Fields & Mind › Water & Electromagnetic Fields › Electromagnetism & Water - Coherence Domains

12. EMMIND › Endogenous Fields & Mind › Endogenous Electromagnetic Fields › Electromagnetism & Microtubules

Very related sections:

expand this introductory text

text updated: 11/05/2016
tables updated: 01/05/2017

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