Theory of affinity maturation of antibodies


" Based on the theory of long distance interaction between antibodies and antigens we developed a theory of affinity maturation of antibodies that is based on longitudinale electric waves. Early stage antibodies show a wide frequency spectrum for antigens and are polyspecific. After affinity maturation the antibody shows a very narrow band spectrum, the antibodies become monospecific. The feedback between anti-body and antibody producing cell is done via messenger molecules that are also communicating with help of longitudinal electric waves. These messenger molecules transfer information from antibody arms and are informing cells whether the epitopes are switched on or off. The folding of antibody is done via eigen frequency resonances."

Because they describe at least two important conceptual deficiencies in an only chemical affinity process of an antibody (when step by step the antibodies become monospecific and the affinity of the produced antibodies increases), they propose that this must be intermediated by (where the binding loops of antigens are represented by electric charged damped oscillators.

" Each chain of an antibody has in the constant region an epitope and also an epitope in the variable region of the antibody chain [9]. Each epitope consists of charged and an uncharged amino acids. So the complete epitope is electrical charged. This charged epitope is oscillating and produces a longitudinal electric wave according to our theory of long distance interaction [5]. We think that epitopes are used for communication with other biological systems."

" ...This gives a feedback to the cell that the antibody is searching for an antigen. Has the antibody found an antigen the binding/binning process reduces the damping of the epitope that is in the variable region of the antibody chain. Now the epitope in the variable region is oscillating with frequency f v and gives the feedback to the B-cell that an antigen is found (the coupled epitope in the variable region stops oscillation). This information can be used for control of affinity maturation."

Also they say that signal transportation must be on electrodynamic basis:

" Messenger molecules that are able to transport information must have an alpha-helix (or a very long beta-sheet) structure inside. We think that both structures are simply nano-sized springs that have the task to realize electrodynamic oscillators in the THz-frequency range."


Last modified on 15-Mar-16

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