Cytoelectric coupling: Electric fields sculpt neural activity and “tune” the brain’s infrastructure

" We propose and present converging evidence for the Cytoelectric Coupling Hypothesis: Electric fields generated by neurons are causal down to the level of the cytoskeleton. This could be achieved via electrodiffusion and mechanotransduction and exchanges between electrical, potential and chemical energy. Ephaptic coupling organizes neural activity, forming neural ensembles at the macroscale level. This information propagates to the neuron level, affecting spiking, and down to molecular level to stabilize the cytoskeleton, “tuning” it to process information more efficiently." {Credits 1}

{Credits 1} 🎪 Pinotsis, D. A., Fridman, G., & Miller, E. K. (2023). Cytoelectric coupling: Electric fields sculpt neural activity and “tune” the brain’s infrastructure. Progress in Neurobiology, 226, 102465. © 2023 The Authors. This article is licensed under a Creative Commons Attribution International 4.0 License..