Ontogenes and Chromosome Nondisjunction in the D. melanogaster Meiosis

" The diversity of meiotic abnormalities, considered above, suggests that the ontogenes are responsible not only for co-orientation of chromosomes, but also for the organization of meiotic division in general." {Credits 1}

" The mechanism underlying the action of ontogenes in meiotically dividing cells. Our results allow us to formulate several points on the kinds of ontogene activities:" {Credits 1}

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" 3) The chromosomes in a meiotically dividing cell are compacted; consequently, the meiotic activity of ontogenes is determined by compacted DNA. The activity of ontogenes in meiosis has a biophysical rather than a chemical nature. All earlier obtained data on the ontogenes [4] [7] [9] exclude their direct involvement in protein synthesis;" {Credits 1}

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" 5) The ability of ontogenes to recognize spatially separated homologs and approach them means that compacted ontogenes form physical (electromagnetic) fields that provide remote interaction; and." {Credits 1}

" 6) According to our results, an ontogene is a discrete hereditary unit represented by a DNA nucleotide sequence, which has a strictly determined conformation and possesses an individual electromagnetic field." {Credits 1}

" It is believed that compaction of the DNA of Mendelian protein-coding genes prohibits them to be active [31] [32]. According to the data of our experiment, compaction of the DNA of ontogenes opens the possibility for ontogenes to be active. The condensed (coiled) regions of ontogenes may be represented as induction coils generating magnetic field during the passage of electric current in a conductor. The hypothesis implying the generation of an electromagnetic field by ontogenes was already proposed when explaining the pairing of two homologs one of which carries an inversion [21]." {Credits 1}

" The idea of electrostatic interaction during meiotic pairing of homologs has been earlier proposed [33] [34]. Our data on a multilateral effect of ontogenes on meiosis suggest a somewhat different explanation. The electromagnetic fields induced by ontogenes serve to attract and orient specialized proteins (for example, tubulins), which are able to perform manifold energy-consuming actions but only in the case of proper orientation in space. This orientation is provided by the fields induced by ontogenes. In this case, the failures in the pairing of homologs and in attachment of univalents and bivalents to the spindle as well as the block of distributive pairing in drosophila meiosis are explainable with a defect in the recruiting of contractile protein molecules." {Credits 1}

{Credits 1} 🎪 Chadov, B. and Fedorova, N. (2022) Ontogenes and Chromosome Nondisjunction in the D. melanogaster Meiosis. Advances in Bioscience and Biotechnology, 13, 317-335. doi: 10.4236/abb.2022.138020. © 2022 The Author(s) and Scientific Research Publishing Inc. This article is licensed under a Creative Commons Attribution 4.0 International License.