Extremely Low-Frequency Electromagnetic Fields Affect Myogenic Processes in C2C12 Myoblasts Role of Gap-Junction-Mediated Intercellular Communication


" although our data do not show clear dose-dependence or threshold-induced effects, ELF-EMFs in the mT intensity range accelerated the myogenic process in these C2C12 myoblasts. In the same cell model, ELF-EMFs can affect the cellular redox state and intracellular Ca2+ dynamics [10] and, consequently, cell metabolic activity. All of these events can be proposed as key triggers involved in increases in specific myogenic markers (e.g., MyoD and myogenin) and the promotion of cell fusion, which is made more efficient by the increased GJIC activity, all of which are steps that can be enhanced by ELF-EMFs."


Last modified on 30-Jun-17

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